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SB 242084
CAS No. 181632-25-7
SB 242084 ( SB-242084;SB242084 )
Catalog No. M12789 CAS No. 181632-25-7
SB 242084 is a potent, selective, brain penetrant 5-HT2C receptor antagonist.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 45 | In Stock |
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| 5MG | 75 | In Stock |
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| 10MG | 105 | In Stock |
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| 25MG | 233 | In Stock |
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| 50MG | 447 | In Stock |
|
| 100MG | 682 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameSB 242084
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NoteResearch use only, not for human use.
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Brief DescriptionSB 242084 is a potent, selective, brain penetrant 5-HT2C receptor antagonist.
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DescriptionSB 242084 is a potent, selective, brain penetrant 5-HT2C receptor antagonist with pKi of 9.0, 100- and 158-fold selectivity over the closely related 5-HT2B and 5-HT2A subtypes; also displays >100-fold selectivity over a range of other 5-HT, dopamine and adrenergic receptors; inhibits 5-HT-stimulated phosphatidylinositol hydrolysis with pKb of 9.3 in cell-baed assays; potently inhibits m-chlorophenylpiperazine (mCPP)-induced hypolocomotion in rats, with an ID50 of 0.11 mg/kg i.p., and 2.0 mg/kg p.o.
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SynonymsSB-242084;SB242084
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PathwayEndocrinology/Hormones
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Target5-HT Receptor
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Recptor5-HT Receptor
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Research AreaNeurological Disease
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Indication——
Chemical Information
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CAS Number181632-25-7
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Formula Weight467.78
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Molecular FormulaC21H19ClN4O2
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 44 mg/mL
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SMILESCC1=CC2=C(C=C1Cl)N(CC2)C(=O)NC3=CN=C(C=C3)OC4=C(N=CC=C4)C.Cl.Cl
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Chemical Name1H-Indole-1-carboxamide, 6-chloro-2,3-dihydro-5-methyl-N-[6-[(2-methyl-3-pyridinyl)oxy]-3-pyridinyl]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Bromidge SM, et al. J Med Chem. 1997 Oct 24;40(22):3494-6.
2. Kennett GA, et al. Neuropharmacology. 1997 Apr-May;36(4-5):609-20.
3. Di Matteo V, et al. Neuropharmacology. 1999 Aug;38(8):1195-205.
2. Kennett GA, et al. Neuropharmacology. 1997 Apr-May;36(4-5):609-20.
3. Di Matteo V, et al. Neuropharmacology. 1999 Aug;38(8):1195-205.
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